Growth hormone (GH) has been used for pharmaceutical purposes (that is, as a drug) since its discovery in the 1950's. originally obtained from the pituitary glands of cadavers, it is now biosynthesized and administered by injection. Although GH is widely used in clinical trials, its use as prescription drug is restricted until its helpful and harmful effects-many of which are intriguing-can be fully documented.
GH is administered legally to children who does not produce it naturally or who have chronic kidney failure, to allow these children to grow to near-normal heights. Unfortunately some physician succumb to parental pressures to prescribe GH to children who do produce it but are extremely short.
When GH is administered to adults with growth-hormone deficiency, body fat decreases and lean body mass, bone density and muscle mass increase. It also appears to increase the performance and muscle mass of the heart, and it decreases blood cholesterol, boosts the immune system, and perhaps improves one's physiological out look. Such effects (particularly those involving increased muscle mass and decreased body fat) have lead to abuse of GH by body builders and athletes, which is one reason why this substance remains restricted.
Because GH may also reverse some effects of aging, anti-aging clinics using GH injections to delay aging are springing up. Many people naturally stop producing GH after 60, and this explain why their ratio of lean-to-fat mass declines and their skin thins. GH is the drug treatment of choice for many aging Hollywood stars who dread the loss of their youth and vitality. Administration of GH to elderly patients reverses these declines. However, clinical studies reveal that the administered GH does not increase strength or exercise tolerance in elderly patients, and careful study of very sick patients in intensive care unit (where GH is routinely given to store nitrogen balance) found that high doses of GH are associated with increased mortality. For these reasons, earlier media claims that GH is a "youth potion" have proven to be dangerously misleading, and GH should not be administered to the very old or critically ill.
GH may help AIDS patients. Because of improved antibiotics, fewer AIDS patients are dying from opportunistic infections. The othe side of this picture is that more die from the weight loss called "wasting". It has been shown that injection of GH can actually reverse wasting during AIDS, leading to weight gain-a gain of lean muscle. In 1996, the U.S. Food and Drugs Administration approved the use of GH to treat such wasting.
GH is not a wonder drug, Even in cases where it is extremely beneficial. GH is expensive and has undesirable side effects. It can lead to fluid retention and edema, joint and muscle pain, high blood sugar, glucose intolerance, and gynecomastia (breast enlargement in males). Hypertention, heart enlargement, diabetes and cancer of the colon are other possible results of high doses of GH, while edema and headaches accompany even the lowest dose. Carefully tailored dosage can avoid most of these side effects however.
Intensive research into the potential benefits of GH is ongoing and should keep this hormone in the public eye for years to come. Let's hope its inbridled use does not become a public health problem.
Growth hormone (GH) has been used for pharmaceutical purposes (that is, as a drug) since its discovery in the 1950's. originally obtained from the pituitary glands of cadavers, it is now biosynthesized and administered by injection. Although GH is widely used in clinical trials, its use as prescription drug is restricted until its helpful and harmful effects-many of which are intriguing-can be fully documented.GH is administered legally to children who does not produce it naturally or who have chronic kidney failure, to allow these children to grow to near-normal heights. Unfortunately some physician succumb to parental pressures to prescribe GH to children who do produce it but are extremely short.
When GH is administered to adults with growth-hormone deficiency, body fat decreases and lean body mass, bone density and muscle mass increase. It also appears to increase the performance and muscle mass of the heart, and it decreases blood cholesterol, boosts the immune system, and perhaps improves one's physiological out look. Such effects (particularly those involving increased muscle mass and decreased body fat) have lead to abuse of GH by body builders and athletes, which is one reason why this substance remains restricted.
Because GH may also reverse some effects of aging, anti-aging clinics using GH injections to delay aging are springing up. Many people naturally stop producing GH after 60, and this explain why their ratio of lean-to-fat mass declines and their skin thins. GH is the drug treatment of choice for many aging Hollywood stars who dread the loss of their youth and vitality. Administration of GH to elderly patients reverses these declines. However, clinical studies reveal that the administered GH does not increase strength or exercise tolerance in elderly patients, and careful study of very sick patients in intensive care unit (where GH is routinely given to store nitrogen balance) found that high doses of GH are associated with increased mortality. For these reasons, earlier media claims that GH is a "youth potion" have proven to be dangerously misleading, and GH should not be administered to the very old or critically ill.
GH may help AIDS patients. Because of improved antibiotics, fewer AIDS patients are dying from opportunistic infections. The othe side of this picture is that more die from the weight loss called "wasting". It has been shown that injection of GH can actually reverse wasting during AIDS, leading to weight gain-a gain of lean muscle. In 1996, the U.S. Food and Drugs Administration approved the use of GH to treat such wasting.
GH is not a wonder drug, Even in cases where it is extremely beneficial. GH is expensive and has undesirable side effects. It can lead to fluid retention and edema, joint and muscle pain, high blood sugar, glucose intolerance, and gynecomastia (breast enlargement in males). Hypertention, heart enlargement, diabetes and cancer of the colon are other possible results of high doses of GH, while edema and headaches accompany even the lowest dose. Carefully tailored dosage can avoid most of these side effects however.
Intensive research into the potential benefits of GH is ongoing and should keep this hormone in the public eye for years to come. Let's hope its inbridled use does not become a public health problem.